Map of how to reach Cohiba Hotel from 
From the airport:
Exit North onto 10th Avenue until reaching Juarez Avenue.
Turn east towards the beach and make a left (North) onto 5th Avenue. Continue down 5th Avenue until you reach Calle 12 and take a right (East)
You will find Hotel Cohiba on the corner of the intersection with 1st Avenue.
From Highway 307:
Upon entering town, either from Tulum or Can Cún pay attention for Jaurez Avenue.
Turn east towards the beach onto Juarez Avenue and continue until 5th Avenue.
Make a left (North) onto 5th Avenue.
Continue down 5th Avenue until you reach Calle 12 and take a right (East)
You will find Hotel Cohiba on the corner of the intersection with 1st Avenue.